diff --git a/ChangeLog.d/tls-hs-defrag-in.txt b/ChangeLog.d/tls-hs-defrag-in.txt
new file mode 100644
index 0000000000..6bab02a029
--- /dev/null
+++ b/ChangeLog.d/tls-hs-defrag-in.txt
@@ -0,0 +1,7 @@
+Bugfix
+   * Support re-assembly of fragmented handshake messages in TLS (both
+     1.2 and 1.3). The lack of support was causing handshake failures with
+     some servers, especially with TLS 1.3 in practice. There are a few
+     limitations, notably a fragmented ClientHello is only supported when
+     TLS 1.3 support is enabled. See the documentation of
+     mbedtls_ssl_handshake() for details.
diff --git a/framework b/framework
index 523a12d05b..8d85112a44 160000
--- a/framework
+++ b/framework
@@ -1 +1 @@
-Subproject commit 523a12d05b91301b020e2aa560d9774135e3a801
+Subproject commit 8d85112a44d052a5d89cb0a135e162384da42584
diff --git a/include/mbedtls/ssl.h b/include/mbedtls/ssl.h
index 958ee9bce7..681584b3d7 100644
--- a/include/mbedtls/ssl.h
+++ b/include/mbedtls/ssl.h
@@ -1782,6 +1782,8 @@ struct mbedtls_ssl_context {
 
     size_t MBEDTLS_PRIVATE(in_hslen);            /*!< current handshake message length,
                                                     including the handshake header   */
+    size_t MBEDTLS_PRIVATE(in_hsfraglen);        /*!< accumulated length of hs fragments
+                                                    (up to in_hslen) */
     int MBEDTLS_PRIVATE(nb_zero);                /*!< # of 0-length encrypted messages */
 
     int MBEDTLS_PRIVATE(keep_current_message);   /*!< drop or reuse current message
@@ -4302,6 +4304,10 @@ void mbedtls_ssl_conf_cert_req_ca_list(mbedtls_ssl_config *conf,
  *                 with \c mbedtls_ssl_read()), not handshake messages.
  *                 With DTLS, this affects both ApplicationData and handshake.
  *
+ * \note           Defragmentation of TLS handshake messages is supported
+ *                 with some limitations. See the documentation of
+ *                 mbedtls_ssl_handshake() for details.
+ *
  * \note           This sets the maximum length for a record's payload,
  *                 excluding record overhead that will be added to it, see
  *                 \c mbedtls_ssl_get_record_expansion().
@@ -4791,6 +4797,24 @@ int mbedtls_ssl_get_session(const mbedtls_ssl_context *ssl,
  *                 currently being processed might or might not contain further
  *                 DTLS records.
  *
+ * \note           In TLS, reception of fragmented handshake messages is
+ *                 supported with some limitations (those limitations do
+ *                 not apply to DTLS, where defragmentation is fully
+ *                 supported):
+ *                 - On an Mbed TLS server that only accepts TLS 1.2,
+ *                   the initial ClientHello message must not be fragmented.
+ *                   A TLS 1.2 ClientHello may be fragmented if the server
+ *                   also accepts TLS 1.3 connections (meaning
+ *                   that #MBEDTLS_SSL_PROTO_TLS1_3 enabled, and the
+ *                   accepted versions have not been restricted with
+ *                   mbedtls_ssl_conf_max_tls_version() or the like).
+ *                 - The first fragment of a handshake message must be
+ *                   at least 4 bytes long.
+ *                 - Non-handshake records must not be interleaved between
+ *                   the fragments of a handshake message. (This is permitted
+ *                   in TLS 1.2 but not in TLS 1.3, but Mbed TLS rejects it
+ *                   even in TLS 1.2.)
+ *
  * \note           The PSA crypto subsystem must have been initialized by
  *                 calling psa_crypto_init() before calling this function.
  */
diff --git a/library/ssl_misc.h b/library/ssl_misc.h
index 9ff0fcaf75..164a23037a 100644
--- a/library/ssl_misc.h
+++ b/library/ssl_misc.h
@@ -1752,10 +1752,11 @@ void mbedtls_ssl_set_timer(mbedtls_ssl_context *ssl, uint32_t millisecs);
 MBEDTLS_CHECK_RETURN_CRITICAL
 int mbedtls_ssl_check_timer(mbedtls_ssl_context *ssl);
 
-void mbedtls_ssl_reset_in_out_pointers(mbedtls_ssl_context *ssl);
+void mbedtls_ssl_reset_in_pointers(mbedtls_ssl_context *ssl);
+void mbedtls_ssl_update_in_pointers(mbedtls_ssl_context *ssl);
+void mbedtls_ssl_reset_out_pointers(mbedtls_ssl_context *ssl);
 void mbedtls_ssl_update_out_pointers(mbedtls_ssl_context *ssl,
                                      mbedtls_ssl_transform *transform);
-void mbedtls_ssl_update_in_pointers(mbedtls_ssl_context *ssl);
 
 MBEDTLS_CHECK_RETURN_CRITICAL
 int mbedtls_ssl_session_reset_int(mbedtls_ssl_context *ssl, int partial);
diff --git a/library/ssl_msg.c b/library/ssl_msg.c
index 97c4866b15..f5ea8dd277 100644
--- a/library/ssl_msg.c
+++ b/library/ssl_msg.c
@@ -2962,19 +2962,34 @@ static uint32_t ssl_get_hs_total_len(mbedtls_ssl_context const *ssl)
 
 int mbedtls_ssl_prepare_handshake_record(mbedtls_ssl_context *ssl)
 {
-    if (ssl->in_msglen < mbedtls_ssl_hs_hdr_len(ssl)) {
-        MBEDTLS_SSL_DEBUG_MSG(1, ("handshake message too short: %" MBEDTLS_PRINTF_SIZET,
-                                  ssl->in_msglen));
-        return MBEDTLS_ERR_SSL_INVALID_RECORD;
-    }
+    if (ssl->in_hsfraglen == 0) {
+        /* The handshake message must at least include the header.
+         * We may not have the full message yet in case of fragmentation.
+         * To simplify the code, we insist on having the header (and in
+         * particular the handshake message length) in the first
+         * fragment. */
+        if (ssl->in_msglen < mbedtls_ssl_hs_hdr_len(ssl)) {
+            MBEDTLS_SSL_DEBUG_MSG(1, ("handshake message too short: %" MBEDTLS_PRINTF_SIZET,
+                                      ssl->in_msglen));
+            return MBEDTLS_ERR_SSL_INVALID_RECORD;
+        }
 
-    ssl->in_hslen = mbedtls_ssl_hs_hdr_len(ssl) + ssl_get_hs_total_len(ssl);
+        ssl->in_hslen = mbedtls_ssl_hs_hdr_len(ssl) + ssl_get_hs_total_len(ssl);
+    }
 
     MBEDTLS_SSL_DEBUG_MSG(3, ("handshake message: msglen ="
                               " %" MBEDTLS_PRINTF_SIZET ", type = %u, hslen = %"
                               MBEDTLS_PRINTF_SIZET,
                               ssl->in_msglen, ssl->in_msg[0], ssl->in_hslen));
 
+    if (ssl->transform_in != NULL) {
+        MBEDTLS_SSL_DEBUG_MSG(4, ("decrypted handshake message:"
+                                  " iv-buf=%d hdr-buf=%d hdr-buf=%d",
+                                  (int) (ssl->in_iv - ssl->in_buf),
+                                  (int) (ssl->in_hdr - ssl->in_buf),
+                                  (int) (ssl->in_msg - ssl->in_buf)));
+    }
+
 #if defined(MBEDTLS_SSL_PROTO_DTLS)
     if (ssl->conf->transport == MBEDTLS_SSL_TRANSPORT_DATAGRAM) {
         int ret = MBEDTLS_ERR_ERROR_CORRUPTION_DETECTED;
@@ -3034,10 +3049,105 @@ int mbedtls_ssl_prepare_handshake_record(mbedtls_ssl_context *ssl)
         }
     } else
 #endif /* MBEDTLS_SSL_PROTO_DTLS */
-    /* With TLS we don't handle fragmentation (for now) */
-    if (ssl->in_msglen < ssl->in_hslen) {
-        MBEDTLS_SSL_DEBUG_MSG(1, ("TLS handshake fragmentation not supported"));
-        return MBEDTLS_ERR_SSL_FEATURE_UNAVAILABLE;
+    {
+        unsigned char *const reassembled_record_start =
+            ssl->in_buf + MBEDTLS_SSL_SEQUENCE_NUMBER_LEN;
+        unsigned char *const payload_start =
+            reassembled_record_start + mbedtls_ssl_in_hdr_len(ssl);
+        unsigned char *payload_end = payload_start + ssl->in_hsfraglen;
+        /* How many more bytes we want to have a complete handshake message. */
+        const size_t hs_remain = ssl->in_hslen - ssl->in_hsfraglen;
+        /* How many bytes of the current record are part of the first
+         * handshake message. There may be more handshake messages (possibly
+         * incomplete) in the same record; if so, we leave them after the
+         * current record, and ssl_consume_current_message() will take
+         * care of consuming the next handshake message. */
+        const size_t hs_this_fragment_len =
+            ssl->in_msglen > hs_remain ? hs_remain : ssl->in_msglen;
+        (void) hs_this_fragment_len;
+
+        MBEDTLS_SSL_DEBUG_MSG(3,
+                              ("%s handshake fragment: %" MBEDTLS_PRINTF_SIZET
+                               ", %" MBEDTLS_PRINTF_SIZET
+                               "..%" MBEDTLS_PRINTF_SIZET
+                               " of %" MBEDTLS_PRINTF_SIZET,
+                               (ssl->in_hsfraglen != 0 ?
+                                "subsequent" :
+                                hs_this_fragment_len == ssl->in_hslen ?
+                                "sole" :
+                                "initial"),
+                               ssl->in_msglen,
+                               ssl->in_hsfraglen,
+                               ssl->in_hsfraglen + hs_this_fragment_len,
+                               ssl->in_hslen));
+
+        /* Move the received handshake fragment to have the whole message
+         * (at least the part received so far) in a single segment at a
+         * known offset in the input buffer.
+         * - When receiving a non-initial handshake fragment, append it to
+         *   the initial segment.
+         * - Even the initial handshake fragment is moved, if it was
+         *   encrypted with an explicit IV: decryption leaves the payload
+         *   after the explicit IV, but here we move it to start where the
+         *   IV was.
+         */
+#if defined(MBEDTLS_SSL_VARIABLE_BUFFER_LENGTH)
+        size_t const in_buf_len = ssl->in_buf_len;
+#else
+        size_t const in_buf_len = MBEDTLS_SSL_IN_BUFFER_LEN;
+#endif
+        if (payload_end + ssl->in_msglen > ssl->in_buf + in_buf_len) {
+            MBEDTLS_SSL_DEBUG_MSG(1,
+                                  ("Shouldn't happen: no room to move handshake fragment %"
+                                   MBEDTLS_PRINTF_SIZET " from %p to %p (buf=%p len=%"
+                                   MBEDTLS_PRINTF_SIZET ")",
+                                   ssl->in_msglen,
+                                   (void *) ssl->in_msg, (void *) payload_end,
+                                   (void *) ssl->in_buf, in_buf_len));
+            return MBEDTLS_ERR_ERROR_CORRUPTION_DETECTED;
+        }
+        memmove(payload_end, ssl->in_msg, ssl->in_msglen);
+
+        ssl->in_hsfraglen += ssl->in_msglen;
+        payload_end += ssl->in_msglen;
+
+        if (ssl->in_hsfraglen < ssl->in_hslen) {
+            MBEDTLS_SSL_DEBUG_MSG(3, ("Prepare: waiting for more handshake fragments %"
+                                      MBEDTLS_PRINTF_SIZET "/%"
+                                      MBEDTLS_PRINTF_SIZET,
+                                      ssl->in_hsfraglen, ssl->in_hslen));
+            ssl->in_hdr = payload_end;
+            ssl->in_msglen = 0;
+            mbedtls_ssl_update_in_pointers(ssl);
+            return MBEDTLS_ERR_SSL_CONTINUE_PROCESSING;
+        } else {
+            ssl->in_msglen = ssl->in_hsfraglen;
+            ssl->in_hsfraglen = 0;
+            ssl->in_hdr = reassembled_record_start;
+            mbedtls_ssl_update_in_pointers(ssl);
+
+            /* Update the record length in the fully reassembled record */
+            if (ssl->in_msglen > 0xffff) {
+                MBEDTLS_SSL_DEBUG_MSG(1,
+                                      ("Shouldn't happen: in_msglen=%"
+                                       MBEDTLS_PRINTF_SIZET " > 0xffff",
+                                       ssl->in_msglen));
+                return MBEDTLS_ERR_ERROR_CORRUPTION_DETECTED;
+            }
+            MBEDTLS_PUT_UINT16_BE(ssl->in_msglen, ssl->in_len, 0);
+
+            size_t record_len = mbedtls_ssl_in_hdr_len(ssl) + ssl->in_msglen;
+            (void) record_len;
+            MBEDTLS_SSL_DEBUG_BUF(4, "reassembled record",
+                                  ssl->in_hdr, record_len);
+            if (ssl->in_hslen < ssl->in_msglen) {
+                MBEDTLS_SSL_DEBUG_MSG(3,
+                                      ("More handshake messages in the record: "
+                                       "%" MBEDTLS_PRINTF_SIZET " + %" MBEDTLS_PRINTF_SIZET,
+                                       ssl->in_hslen,
+                                       ssl->in_msglen - ssl->in_hslen));
+            }
+        }
     }
 
     return 0;
@@ -4382,6 +4492,14 @@ static int ssl_consume_current_message(mbedtls_ssl_context *ssl)
             return MBEDTLS_ERR_SSL_INTERNAL_ERROR;
         }
 
+        if (ssl->in_hsfraglen != 0) {
+            /* Not all handshake fragments have arrived, do not consume. */
+            MBEDTLS_SSL_DEBUG_MSG(3, ("Consume: waiting for more handshake fragments %"
+                                      MBEDTLS_PRINTF_SIZET "/%" MBEDTLS_PRINTF_SIZET,
+                                      ssl->in_hsfraglen, ssl->in_hslen));
+            return 0;
+        }
+
         /*
          * Get next Handshake message in the current record
          */
@@ -4407,6 +4525,7 @@ static int ssl_consume_current_message(mbedtls_ssl_context *ssl)
             ssl->in_msglen -= ssl->in_hslen;
             memmove(ssl->in_msg, ssl->in_msg + ssl->in_hslen,
                     ssl->in_msglen);
+            MBEDTLS_PUT_UINT16_BE(ssl->in_msglen, ssl->in_len, 0);
 
             MBEDTLS_SSL_DEBUG_BUF(4, "remaining content in record",
                                   ssl->in_msg, ssl->in_msglen);
@@ -4770,6 +4889,18 @@ int mbedtls_ssl_handle_message_type(mbedtls_ssl_context *ssl)
 {
     int ret = MBEDTLS_ERR_ERROR_CORRUPTION_DETECTED;
 
+    /* If we're in the middle of a fragmented TLS handshake message,
+     * we don't accept any other message type. For TLS 1.3, the spec forbids
+     * interleaving other message types between handshake fragments. For TLS
+     * 1.2, the spec does not forbid it but we do. */
+    if (ssl->conf->transport == MBEDTLS_SSL_TRANSPORT_STREAM &&
+        ssl->in_hsfraglen != 0 &&
+        ssl->in_msgtype != MBEDTLS_SSL_MSG_HANDSHAKE) {
+        MBEDTLS_SSL_DEBUG_MSG(1, ("non-handshake message in the middle"
+                                  " of a fragmented handshake message"));
+        return MBEDTLS_ERR_SSL_UNEXPECTED_MESSAGE;
+    }
+
     /*
      * Handle particular types of records
      */
@@ -5081,7 +5212,7 @@ void mbedtls_ssl_update_in_pointers(mbedtls_ssl_context *ssl)
     } else
 #endif
     {
-        ssl->in_ctr = ssl->in_hdr - MBEDTLS_SSL_SEQUENCE_NUMBER_LEN;
+        ssl->in_ctr = ssl->in_buf;
         ssl->in_len = ssl->in_hdr + 3;
 #if defined(MBEDTLS_SSL_DTLS_CONNECTION_ID)
         ssl->in_cid = ssl->in_len;
@@ -5097,24 +5228,35 @@ void mbedtls_ssl_update_in_pointers(mbedtls_ssl_context *ssl)
  * Setup an SSL context
  */
 
-void mbedtls_ssl_reset_in_out_pointers(mbedtls_ssl_context *ssl)
+void mbedtls_ssl_reset_in_pointers(mbedtls_ssl_context *ssl)
+{
+#if defined(MBEDTLS_SSL_PROTO_DTLS)
+    if (ssl->conf->transport == MBEDTLS_SSL_TRANSPORT_DATAGRAM) {
+        ssl->in_hdr = ssl->in_buf;
+    } else
+#endif  /* MBEDTLS_SSL_PROTO_DTLS */
+    {
+        ssl->in_hdr = ssl->in_buf + MBEDTLS_SSL_SEQUENCE_NUMBER_LEN;
+    }
+
+    /* Derive other internal pointers. */
+    mbedtls_ssl_update_in_pointers(ssl);
+}
+
+void mbedtls_ssl_reset_out_pointers(mbedtls_ssl_context *ssl)
 {
     /* Set the incoming and outgoing record pointers. */
 #if defined(MBEDTLS_SSL_PROTO_DTLS)
     if (ssl->conf->transport == MBEDTLS_SSL_TRANSPORT_DATAGRAM) {
         ssl->out_hdr = ssl->out_buf;
-        ssl->in_hdr  = ssl->in_buf;
     } else
 #endif /* MBEDTLS_SSL_PROTO_DTLS */
     {
         ssl->out_ctr = ssl->out_buf;
-        ssl->out_hdr = ssl->out_buf + 8;
-        ssl->in_hdr  = ssl->in_buf  + 8;
+        ssl->out_hdr = ssl->out_buf + MBEDTLS_SSL_SEQUENCE_NUMBER_LEN;
     }
-
     /* Derive other internal pointers. */
     mbedtls_ssl_update_out_pointers(ssl, NULL /* no transform enabled */);
-    mbedtls_ssl_update_in_pointers(ssl);
 }
 
 /*
diff --git a/library/ssl_tls.c b/library/ssl_tls.c
index ec4272a05f..3572f3f631 100644
--- a/library/ssl_tls.c
+++ b/library/ssl_tls.c
@@ -339,12 +339,13 @@ static void handle_buffer_resizing(mbedtls_ssl_context *ssl, int downsizing,
                                    size_t out_buf_new_len)
 {
     int modified = 0;
-    size_t written_in = 0, iv_offset_in = 0, len_offset_in = 0;
+    size_t written_in = 0, iv_offset_in = 0, len_offset_in = 0, hdr_in = 0;
     size_t written_out = 0, iv_offset_out = 0, len_offset_out = 0;
     if (ssl->in_buf != NULL) {
         written_in = ssl->in_msg - ssl->in_buf;
         iv_offset_in = ssl->in_iv - ssl->in_buf;
         len_offset_in = ssl->in_len - ssl->in_buf;
+        hdr_in = ssl->in_hdr - ssl->in_buf;
         if (downsizing ?
             ssl->in_buf_len > in_buf_new_len && ssl->in_left < in_buf_new_len :
             ssl->in_buf_len < in_buf_new_len) {
@@ -376,7 +377,10 @@ static void handle_buffer_resizing(mbedtls_ssl_context *ssl, int downsizing,
     }
     if (modified) {
         /* Update pointers here to avoid doing it twice. */
-        mbedtls_ssl_reset_in_out_pointers(ssl);
+        ssl->in_hdr = ssl->in_buf + hdr_in;
+        mbedtls_ssl_update_in_pointers(ssl);
+        mbedtls_ssl_reset_out_pointers(ssl);
+
         /* Fields below might not be properly updated with record
          * splitting or with CID, so they are manually updated here. */
         ssl->out_msg = ssl->out_buf + written_out;
@@ -1274,7 +1278,8 @@ int mbedtls_ssl_setup(mbedtls_ssl_context *ssl,
         goto error;
     }
 
-    mbedtls_ssl_reset_in_out_pointers(ssl);
+    mbedtls_ssl_reset_in_pointers(ssl);
+    mbedtls_ssl_reset_out_pointers(ssl);
 
 #if defined(MBEDTLS_SSL_DTLS_SRTP)
     memset(&ssl->dtls_srtp_info, 0, sizeof(ssl->dtls_srtp_info));
@@ -1339,7 +1344,8 @@ void mbedtls_ssl_session_reset_msg_layer(mbedtls_ssl_context *ssl,
     /* Cancel any possibly running timer */
     mbedtls_ssl_set_timer(ssl, 0);
 
-    mbedtls_ssl_reset_in_out_pointers(ssl);
+    mbedtls_ssl_reset_in_pointers(ssl);
+    mbedtls_ssl_reset_out_pointers(ssl);
 
     /* Reset incoming message parsing */
     ssl->in_offt    = NULL;
@@ -1347,6 +1353,7 @@ void mbedtls_ssl_session_reset_msg_layer(mbedtls_ssl_context *ssl,
     ssl->in_msgtype = 0;
     ssl->in_msglen  = 0;
     ssl->in_hslen   = 0;
+    ssl->in_hsfraglen = 0;
     ssl->keep_current_message = 0;
     ssl->transform_in  = NULL;
 
diff --git a/library/ssl_tls12_server.c b/library/ssl_tls12_server.c
index fc9b860543..a302af48ed 100644
--- a/library/ssl_tls12_server.c
+++ b/library/ssl_tls12_server.c
@@ -1015,28 +1015,6 @@ read_record_header:
         MBEDTLS_SSL_DEBUG_MSG(1, ("bad client hello message"));
         return MBEDTLS_ERR_SSL_UNEXPECTED_MESSAGE;
     }
-    {
-        size_t handshake_len = MBEDTLS_GET_UINT24_BE(buf, 1);
-        MBEDTLS_SSL_DEBUG_MSG(3, ("client hello v3, handshake len.: %u",
-                                  (unsigned) handshake_len));
-
-        /* The record layer has a record size limit of 2^14 - 1 and
-         * fragmentation is not supported, so buf[1] should be zero. */
-        if (buf[1] != 0) {
-            MBEDTLS_SSL_DEBUG_MSG(1, ("bad client hello message: %u != 0",
-                                      (unsigned) buf[1]));
-            return MBEDTLS_ERR_SSL_DECODE_ERROR;
-        }
-
-        /* We don't support fragmentation of ClientHello (yet?) */
-        if (msg_len != mbedtls_ssl_hs_hdr_len(ssl) + handshake_len) {
-            MBEDTLS_SSL_DEBUG_MSG(1, ("bad client hello message: %u != %u + %u",
-                                      (unsigned) msg_len,
-                                      (unsigned) mbedtls_ssl_hs_hdr_len(ssl),
-                                      (unsigned) handshake_len));
-            return MBEDTLS_ERR_SSL_DECODE_ERROR;
-        }
-    }
 
 #if defined(MBEDTLS_SSL_PROTO_DTLS)
     if (ssl->conf->transport == MBEDTLS_SSL_TRANSPORT_DATAGRAM) {
diff --git a/programs/ssl/ssl_test_lib.h b/programs/ssl/ssl_test_lib.h
index 6fc3d73072..bc5cce51a0 100644
--- a/programs/ssl/ssl_test_lib.h
+++ b/programs/ssl/ssl_test_lib.h
@@ -243,8 +243,8 @@ int key_opaque_set_alg_usage(const char *alg1, const char *alg2,
  * - free the provided PK context and re-initilize it as an opaque PK context
  *   wrapping the PSA key imported in the above step.
  *
- * \param[in/out] pk    On input the non-opaque PK context which contains the
- *                      key to be wrapped. On output the re-initialized PK
+ * \param[in,out] pk    On input, the non-opaque PK context which contains the
+ *                      key to be wrapped. On output, the re-initialized PK
  *                      context which represents the opaque version of the one
  *                      provided as input.
  * \param[in] psa_alg   The primary algorithm that will be associated to the
diff --git a/scripts/make_generated_files.bat b/scripts/make_generated_files.bat
index 4982f77dba..bef198f361 100644
--- a/scripts/make_generated_files.bat
+++ b/scripts/make_generated_files.bat
@@ -32,4 +32,5 @@ python framework\scripts\generate_psa_tests.py --directory tf-psa-crypto\tests\s
 python framework\scripts\generate_test_keys.py --output framework\tests\include\test\test_keys.h || exit /b 1
 python tf-psa-crypto\framework\scripts\generate_test_keys.py --output tf-psa-crypto\framework\tests\include\test\test_keys.h || exit /b 1
 python framework\scripts\generate_test_cert_macros.py --output tests\src\test_certs.h || exit /b 1
+python framework\scripts\generate_tls_handshake_tests.py || exit /b 1
 python framework\scripts\generate_tls13_compat_tests.py || exit /b 1
diff --git a/tests/.gitignore b/tests/.gitignore
index 997101cc80..a4a0309fa8 100644
--- a/tests/.gitignore
+++ b/tests/.gitignore
@@ -18,6 +18,7 @@
 
 ###START_GENERATED_FILES###
 # Generated source files
+/opt-testcases/handshake-generated.sh
 /opt-testcases/tls13-compat.sh
 /suites/*.generated.data
 /suites/test_suite_config.mbedtls_boolean.data
diff --git a/tests/CMakeLists.txt b/tests/CMakeLists.txt
index 950c365973..a56a707f41 100644
--- a/tests/CMakeLists.txt
+++ b/tests/CMakeLists.txt
@@ -57,6 +57,24 @@ if(GEN_FILES)
             # change too often in ways that don't affect the result
             # ((un)commenting some options).
     )
+
+    add_custom_command(
+        OUTPUT
+            ${CMAKE_CURRENT_SOURCE_DIR}/opt-testcases/handshake-generated.sh
+        WORKING_DIRECTORY
+            ${CMAKE_CURRENT_SOURCE_DIR}/..
+        COMMAND
+            "${MBEDTLS_PYTHON_EXECUTABLE}"
+            "${CMAKE_CURRENT_SOURCE_DIR}/../framework/scripts/generate_tls_handshake_tests.py"
+        DEPENDS
+            ${CMAKE_CURRENT_SOURCE_DIR}/../framework/scripts/mbedtls_framework/tls_test_case.py
+            ${CMAKE_CURRENT_SOURCE_DIR}/../framework/scripts/generate_tls_handshake_tests.py
+    )
+    add_custom_target(handshake-generated.sh
+        DEPENDS ${CMAKE_CURRENT_SOURCE_DIR}/opt-testcases/handshake-generated.sh)
+    set_target_properties(handshake-generated.sh PROPERTIES EXCLUDE_FROM_ALL NO)
+    add_dependencies(${ssl_opt_target} handshake-generated.sh)
+
     add_custom_command(
         OUTPUT
             ${CMAKE_CURRENT_SOURCE_DIR}/opt-testcases/tls13-compat.sh
diff --git a/tests/Makefile b/tests/Makefile
index 7bd9953422..b6f2f8caff 100644
--- a/tests/Makefile
+++ b/tests/Makefile
@@ -64,6 +64,13 @@ GENERATED_FILES += ../framework/tests/include/test/test_keys.h \
 # Generated files needed to (fully) run ssl-opt.sh
 .PHONY: ssl-opt
 
+opt-testcases/handshake-generated.sh: ../framework/scripts/mbedtls_framework/tls_test_case.py
+opt-testcases/handshake-generated.sh: ../framework/scripts/generate_tls_handshake_tests.py
+	echo "  Gen   $@"
+	$(PYTHON) ../framework/scripts/generate_tls_handshake_tests.py -o $@
+GENERATED_FILES += opt-testcases/handshake-generated.sh
+ssl-opt: opt-testcases/handshake-generated.sh
+
 opt-testcases/tls13-compat.sh: ../framework/scripts/generate_tls13_compat_tests.py
 	echo "  Gen   $@"
 	$(PYTHON) ../framework/scripts/generate_tls13_compat_tests.py -o $@
diff --git a/tests/scripts/check-generated-files.sh b/tests/scripts/check-generated-files.sh
index 8cc341d177..ba10024ee8 100755
--- a/tests/scripts/check-generated-files.sh
+++ b/tests/scripts/check-generated-files.sh
@@ -179,6 +179,7 @@ if in_mbedtls_repo; then
     check scripts/generate_query_config.pl programs/test/query_config.c
     check scripts/generate_features.pl library/version_features.c
     check framework/scripts/generate_ssl_debug_helpers.py library/ssl_debug_helpers_generated.c
+    check framework/scripts/generate_tls_handshake_tests.py tests/opt-testcases/handshake-generated.sh
     check framework/scripts/generate_tls13_compat_tests.py tests/opt-testcases/tls13-compat.sh
     check framework/scripts/generate_test_cert_macros.py tests/src/test_certs.h
     # generate_visualc_files enumerates source files (library/*.c). It doesn't
diff --git a/tests/ssl-opt.sh b/tests/ssl-opt.sh
index 75ab93861b..0736d0e3d0 100755
--- a/tests/ssl-opt.sh
+++ b/tests/ssl-opt.sh
@@ -13705,6 +13705,20 @@ run_test    "TLS 1.2 ClientHello indicating support for deflate compression meth
             -c "Handshake was completed" \
             -s "dumping .client hello, compression. (2 bytes)"
 
+# Handshake defragmentation testing
+
+# Most test cases are in opt-testcases/handshake-generated.sh
+
+requires_config_enabled MBEDTLS_SSL_PROTO_TLS1_2
+requires_certificate_authentication
+run_test    "Handshake defragmentation on server: len=32, TLS 1.2 ClientHello" \
+            "$P_SRV debug_level=4 force_version=tls12 auth_mode=required" \
+            "$O_NEXT_CLI -tls1_2 -split_send_frag 32 -cert $DATA_FILES_PATH/server5.crt -key $DATA_FILES_PATH/server5.key" \
+            1 \
+            -s "The SSL configuration is tls12 only" \
+            -s "bad client hello message" \
+            -s "SSL - A message could not be parsed due to a syntactic error"
+
 # Test heap memory usage after handshake
 requires_config_enabled MBEDTLS_SSL_PROTO_TLS1_2
 requires_config_enabled MBEDTLS_MEMORY_DEBUG